The relationship between ACE I/D gene polymorphism rs4646994 and incidence and severityof sport injuries in Iranian male elite weightlifters

Introduction: despite careful control of environmental factors, there is a wide variety of interpersonal muscle-induced muscle damage. genetic changes can also be important in determining susceptibility to injury. weightlifting is one of the most successful iranian sports teams in olympics; so, the aim of this study was the investigation of the relationship between ace i/d gene polymorphism rs4646994 and incidence and severity of sport injuries in iranian male eliteweightlifters. materials and methods: the study was cross-sectional research that conducted in 2022. the statistical population consisted of male elite weightlifters from isfahan consisting of 31 athletes who all were investigated as sample. a questionnaire was used to collect the injuries data. saliva samples were taken from all subjects and dna was extracted and genotyped by using real-time polymerase chain reaction (real time-pcr). chi-square and regression tests were used to analyze the data. significance level was also considered at p <0.05. results: there was a significant difference in the incidence of injuries in different genotypes. id genotype (59.4%) had the highest incidence of injury in compare with dd (23.2%) and ii (17.4%) genotypes (χ2 = 21.47, p = 0.001). also, there was a significant difference in the severity of injuries in different genotypes (χ2 =15.59, p = 0.049); but there was no relationship between genotype and incidence and the severity of sports injuries in selected iranian elite male weightlifters (p= 0.715). conclusion: the results showed differences in the incidence and severity of sport injuries in different genotypes, hence it would be important in the prediction injury risk in weightlifters.