the impact of specific physical training on fgf-2 and vegf-a expression in patients post-coronary artery bypass surgery

Introduction:  coronary artery bypass surgery (cabg) is a common procedure for patients with coronary artery disease. this study aimed to investigate the effect of selected physical exercises on the expression of fgf-2 and vegf-a in patients post-cabg.material & methods: in this semi-experimental study, 20 male patients from afshar hospital (yazd city) who had undergone cabg were selected and randomly divided into two groups: a combined training group and a control group. the combined training group performed an 8-week program consisting of endurance training (15-20 minutes at 50-60% of hrmax) and resistance training (10-20 minutes, including three upper limb and two lower limb movements, each with three sets of 10 repetitions at 30-60% of 1rm), conducted three times per week. gene expression of fibroblast growth factor 2 (fgf-2) and vascular endothelial growth factor a (vegf-a) was measured using real-time pcr. data were analyzed using paired t-tests and one-way anova with a significance level set at p<0.05.results: an increase in the expression of vegf and fgf-2 genes was observed in the combined training group post-test compared to pre-test (p=0.019). additionally, there was a significant difference in vegf gene expression between the control and training groups (p=0.016). significant differences were also found in fgf-2 expression between the combined exercise group and both the healthy control and patient control groups (p=0.001 for both).conclusion: the results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in cabg patients by increasing growth factor expression.