comparison of hif1 gene polymorphism (rs11549465) among elite and amateur karate-kas versus non-athletes

Introduction: one of the major energy systems for power performance in muscles is glycolysis that is regulated by the levels of hypoxia-inducible factor-1α (hif1), which acts as a transcription factor in response to hypoxia. the purpose of this study was to compare the hif1 gene polymorphism (rs11549465) between elite and amateur power karate-kas versus non-athletes.materials and methods: in this survey, the c/t polymorphism allelic and genotypic distribution of the “hif1 rs11549465” gene was detected in 550 healthy iranian persons who were divided into three groups: elite karate-kas (86 males and 86 females) and amateur karate-kas (100 males and 72 females) versus 206 non-athletes (100 males and 106 females).  5 cc blood was taken for dna extraction and the hif1 gene t/c polymorphism was determined by pcr from the extracted dna. also, rflp analyses was exerted by electrophoresis separation. statistical analyses included chi-square and multinomial regression tests and data with p < 0.05 were considered to be a significant amount.results: the distribution of hif1 c/t genotype in the groups was significantly different in all of subjects (tc: 25.6%; tt: 11.4% and cc: 63%) (χ2 = 99.889, p = 0.0001), but it was not different between the groups significantly (p > 0.05). furthermore, multiple regression analysis demonstrated that the genotype of hif1 was not related to the karate-ka’s athletic status.conclusion: in iranian population, the hif1 gene c/t polymorphism is not related to the karate-ka athletic status.