The effect of three month combined training on the serum levels of interleukin-6 and Creactiveprotein in sedentary obese women

Introduction: combined training play important role in improvingbody composition, but less is known about its anti-inflammatorymechanism in obesity. researcher in the present study investigatedthe effect of three-month combined exercise training on the serumlevels of interleukin-6 and c-reactive protein in sedentary obesewomen.materials and methods: the 24 obese women age ranging 20-35years old with average body mass index (bmi) 32.02±1.03 kg/m2randomly allocated in 2 groups (12 participants in each group)including control and combined training (endurance-resistance)groups. exercise training program conducted for 12 weeks and threesession per week. endurance training intensity was 60 percent ofreserve heart rate and resistance training intensity was 75 percent of1rm. blood samples collected before and after 12 weeks trainingprogram and il-6 and crp levels were measured by elisa method.data were analyzed by means of spss software version 24 withanalysis of covariance test.results: present study findings indicated that serum levels of il-6 incombined training group significantly decreased compared to controlgroup (p < 0.001). in addition, significant decrease in crp levelswere observed in combined training group compared to control group(p = 0.0188), which decrease in inflammatory mediators wasassociated with significant decrease in percent body fat in combinedtraining group (p < 0.001).conclusion: according to present study, combined training plays animportant role in down-regulation of inflammatory mediators and theanti-inflammatory effect may be related to decrease in body fat massas a main source for secreting the inflammatory mediators includingcrp and il-6.