High intensity aerobic interval training and curcumin supplementation could controlhippocampal neurotoxicity induced by oxygenated water consumption in male rats

Introduction: tissue dysfunction might be the result of reactionsbetween free radicals and cell membranes. the purpose of thisstudy was the evaluation of cell vulnerability and assessment ofthe effect of intense intermittent exercise and curcuminsupplementation on apoptotic and antiapoptotic factors in wistarrats.materials and methods: for the study, 60 adult male wistar ratswere randomly divided to 5 groups (n = 8) of saline, hydrogenperoxide (h2o2), high intensity interval training (hiit) +oxygenated water, curcumin supplement + oxygenated water,and hiit + curcumin supplement + oxygenated water. ratswere treated with h2o2 in the amount of 1 mmol/kg of bodyweight three times a week on even days and curcumin, 150 mg/kg of body weight, daily. treadmill running program wasperformed for 8 weeks. real-time pcr was applied to assess bcl-2-associated x protein (bax) and b-cell lymphoma 2 (bcl-2)genes expression. data were analyzed by using the two-wayanova.results: the induction of oxidative stress by h2o2 increasedexpression of bax, and decreased expression of bcl-2 inhippocampus of rats (p = 0.0001). hiit and curcuminsupplementation decreased expression of bax, and increasedexpression of bcl-2, also, decreased the bax/bcl-2 ratio (p =0.0001).conclusion: this finding showed that doing hiit and takingcurcumin supplements have been able to decreas oxidative stress,and the effect of both together could further reduce the apoptoticprocess.