The effect of high, low and moderate intensity circuit resistance training on the levels ofhepatocyte-derived fibrinogen-related protein 1 (HFREP1) and lipid profile in obesepostmenopausal women

Introduction: different hepatokines including the hepatocyte-derived fibrinogen-related protein 1(hfrep1) are secreted by liver tissue, which can affect the lipid metabolism. the aim of presentstudy was to investigate the effect of 12 weeks circuit resistance training with different intensity onthe levels of hfrep1 and lipid profile in obese postmenopausal women.materials and methods: subjects of the study consisted of 44 postmenopausal women with averageage of 56.07 ± 3.18 years old, dividing into the circuit resistance training with low (l-rt), moderate(m-rt), high (h-rt) intensity and the control groups (11 subjects in each group). training programwas conducted for 12 weeks and three session per week. blood samples collected in pre and post-teststages and the levels of hfrep1 were measured by elisa method and finally data was analyzed bygraphpad prism software.results: analysis of hfrep1 data indicated that there were significant differences between differentgroups (p < 0.001). the results of bonferroni post hoc-test showed that there was no significantdifference between the control and l-rt groups (p > 0.05). however, hfrep1 in m-rt and h-rtgroups significantly decreased compared to control group (p < 0.001). in addition, hfrep1 decreasein m-rt and h-rt groups was significant compared to l-rt group (p > 0.05). lipid profile alsoimproved in all trained groups, which further improvement observed in the h-rt group.conclusion: it seems that, higher intensity circuit resistance training is associated with furtherdecrease in the levels of hfrep1, and improving the lipid profile can be attributed partly todownregulation of hfrep-1 levels.