The effect of eight weeks of HIIT on some angiogenesis indices of apelin-13 in elderly malerats

Introduction: aging causes changes in metabolic, cardiovascular, and neuromuscular functions. bydeveloping aging process, physical activity decreases, which is mainly due to fundamental changes in bodycomposition and lack of angiogenesis for which some indicators of angiogenesis have been found in oldermale mice. the purpose of this study was to investigate the effect of high-intensity interval training (hiit)on angiogenesis indices in elderly male rats.materials and methods: the studied sample included 20 elderly male mice, which were randomly dividedinto two groups of control (n = 10) and experimental (n = 10). the experimental group repeated the hiitin the specified intervals. the exercises were repeated after two minutes of rest, with 80% of the maximumspeed in the first week, 90% in the second week, 100% in the third week, and 110% from the beginning ofthe fourth week, until the end of the training. to evaluate the research variables (vegf, fgf21, no, apelin-13), 3 ml of peripheral blood was drawn from the tail of elderly male mice 72 hours before and after thelast session of the training.results: eight weeks of hiit significantly increased vegf and no (p = 0.001). it also increased the fgfand apelin-3 levels significantly (p = 0.0001). no significant change was observed in the control group.conclusion: the results of this study showed that eight weeks of hiit significantly increased angiogenesislevels in elderly male rats. therefore, hiit can be used as an appropriate and especially alternative exerciseto increase angiogenesis in the elderly individuals.