Effect of Grape Seed Extract Consumption along with Moderate Intensity AerobicTraining on Some Biomarkers of Apoptosis of Cardiomyocytes in Wistar Rats withType 1 Diabetes

Introduction: today, diabetes is one of the leading causes of death in worldwide. nutritionalintervention and exercise training known as main strategies for control and management diabetes. theaim of the present study was to investigate the effect of grape seed extract consumption with moderateintensity aerobic exercise on some markers of cardiac myocyte apoptosis in male wistar rats with type1 diabetic.materials and methods: forty adult male wistar rats with an initial weight range of 160-220 g weredivided into 5 groups of including diabetic / training + extract, diabetic / training, diabetic / extract,diabetic / control and healthy / control (8 heads per group). the rats of training groups performedaerobic exercise for 60 minutes a day at an average speed of 28 meters per minute (intensity equivalentto 70 to 75% of maximum oxygen consumption and training volume of 8.4 km per week). grape seedextract was consumed by gavage with dosage of 40 mg / kg per day. all groups 48 hours after the lasttraining session, was dissected and heart tissue was collected and bcl-2, sfas and fasl analysis wasperformed.results: aerobic training and consumption of grape seed extract (both and each alone) significantlyincreased fasl and bcl-2 and also significantly decreased sfas and sfas/fasl in type 1 diabetic rats(p < 0.05); however, the combination of aerobic training and consumption of grape seed extractincreased fasl and bcl-2 further and also decreased sfas and sfas/fasl in these rats compared to thetraining and consumption of the extract alone, which was a statistically significant difference (p < 0.05).conclusion: by combining the antioxidant and anti-inflammatory effects of moderate-intensity aerobicexercise along with the consumption of grape seed extract, more anti-apoptotic effects may be inducedin the myocytes of type 1 diabetic rats.