The effect of high-intensity interval training on inflammatory markers in male ratsundergoing X-ray radiation

Introduction: one of the famous cancer treatments that are associated with an increment ininflammatory factors is x-ray radiation. this study aimed to evaluate the effect of high-intensityinterval training on inflammatory markers in male rats undergoing x-ray radiation.materials and methods: in this experimental study, 24 male rats were randomly divided into 4groups: healthy control (n=6), hiit (n=6), x-ray radiation (n=6) and x-ray radiation + hiit (n=6).first, x-ray radiation and hiit + x-ray radiation groups were anesthetized with ketamine xylazinesolution (k, 60-90 kg/mg; z, 6-10 kg/mg) and then placed on a 1 cm thick plexiglas plate. the x-rayradiation photon beam was performed using x-ray with 4 gy linear accelerators (elekta compact 6-mv china). the training program included ten weeks of hiit. serum levels of tumor necrosisfactor alpha (tnf-α) and interleukin-6 (il-6) were measured by rat elisa kits. one-way anovawas used to determine the existence of a significant difference among groups.results: the results showed a significant difference between tnf-α and il-6 in the hiit, x-rayradiation, and hiit + x-ray radiation groups with the control group (p < 0.05), but there was nosignificant difference between these three groups (p > 0.05).conclusion: x-ray radiation can increase tnf-α and il-6. hiit, on the other hand, can also enhancethese factors. it seems better for people undergoing radiotherapy to use another exercise traininginstead of hiit.