effects of aerobic training and omega-3 supplementation on the levels of crp, mda and lipid profile in overweight and obese women

Introduction: exercise training and omega 3 supplements play an important role in modulating the levels of oxidative and inflammatory mediators. the present study conducted aimed to investigate the effects of aerobic training and omega-3 supplementation on the levels of oxidative (mda) and inflammatory (crp) mediators and lipid profile in overweight and obese women.materials and methods: the 40 overweight and obese women (bmi = 29.1 ± 6.9 kg/m2) randomly assigned to four groups (10 subjects in each group) including placebo (c), omega-3 (s), training (t) and training + omega 3 (st) groups. aerobic training program was performed with 50-70 percent of maximum heart rate for eight weeks/three sessions per week. daily 2000 mg omega 3 supplement were also consumed by s and st groups. the mda, crp and lipid profile levels were measured and data were analyzed by spss software (version 24).results: significant decrease in crp levels in s (p = 0.014), t (p = 0.030) and st (p < 0.001) groups compared to c group, and significant decrease in mda levels in t and st groups compared to c and s groups were observed (p < 0.05). in addition, lipid profile indicated a significant improvement in t and st groups (p < 0.05).conclusion: despite the aerobic training and training + omega-3 supplement effects in decreasing levels of crp, mda and lipid profile improvement, no significant difference was observed between the two groups. it seems that, eight weeks omega-3 ingestion along with aerobic training don’t exert a synergistic effect.