the effect of aerobic exercise and a synthesized insulin nanocomposite hydrogel on tnf-α and il-6 in plasma of type 1 diabetic rats

Introduction: diabetes is one of the leading causes of mortality in the world. the present study aimed to investigate the effect of aerobic exercise training and a synthesized insulin nanocomposite hydrogel on tnf alpha; and il6 in type 1 diabetic rats.materials and methods: twentyfive rats were divided into five equal groups of animals each containing five animals, control healthy, controldiabetes, nanoinsulin diabetes, exercise diabetes and nanoinsulin diabetesexercise. the exercise training program lasted eight weeks. after the five days of familiarization, exercise time for the exercise groups were as follows: 20 m/min for the first and second weeks, 25 m/min for the third and fourth weeks and 30 m / min for the fifth and sixth weeks. the rats were also given the nanoinsulin supplement. rats were killed 48 hours after the last training session. their plasma was taken and used for the analysis of markers. results: there were significant differences in il6 (p<0.001) and tnf alpha; (p<0.001) between the groups.conclusion: the results of this study showed that aerobic exercise training along with nanoinsulin supplementation significantly reduced tnf alpha; and il6 in rats with type 1 diabetes and these changes were more in the nanoinsulin diabetes group.