the effect of twelve weeks of combined training with and without canagliflozin consumption on fetuin a and fetuin b in type 2 diabetic men

Introduction: cardiovascular disease, diabetes, and fatty liver are now considered the major causes of mortality in developing countries. the present study investigates the effect of twelve weeks of combined training with and without canagliflozin consumption on fetuin a and fetuin b in type 2 diabetic men.materials and methods: forty four men (2540 years ) who had type two diabitiac were recruited for this study. this is a double blind study conducted in four groups. for this purpose, diabetic men were divided into four groups of 11 individuals, including control diabetes, diabetes medication, diabetes training, and diabetes training supplementation. every day, 200 mg of canagliflozin and placebo were given to medication consuming and placebo groups. blood samples were taken before and 48 hours after the last training session and used for analysis.results: twoway anova results showed a significant difference between groups (p<0.001) for fetuin aamounts. bonferroni test results also showed a significant difference between control and training (p = 0.030), control and medication training (p<0.001), medication training, and medication (p<0.001) and medication training and training (p= 0.001) groups. the two-way analysis of variance showed significant differences between groups (p = 0.023) in terms of fetuin b amounts. the post hoc test results showed a significant difference between control and training groups (p = 0.009) and control with training medication groups (p = 0.007).conclusion: according to our results, the administration of a combination program, alongside the use of canagliflozin, on individuals who have type 2 diabetes may have the most significant effect on reducing these hepatokines in people with diabetes.