lack of association between insulin-like growth factor-i (igf-i) gene polymorphism (rs35767) and power performance in professional, amateur athletes and non-athlete individuals in iranian population

Introduction: genetic variation between individuals may include single nucleotide polymorphisms. these individual differences could change human phenotypes (such as skeletal structure, heart and lung size). insulinlike growth factori (igfi) is a critical factor in growth and exerciseassociated muscle development. in this study we analyzed the frequency of igfi rs35767 polymorphism in karatekas athletes to find whether there is a difference among professional, amateur athletes and non karatekas. materials and methods: two hundred and fiftyfour athletes (95 professional karatekas, and 159 amateur karatekas) and 159 nonathletic healthy individuals participated in the current study. following provision of informed consent, 2 ml of blood samples were taken. after dna isolation, the genotyping frequencies of the igfi gene c/t polymorphism was assessed by restriction fragment length polymorphism (rflp) analysis. statistical analyses carried out using spss software (version 20) and data with p<0.05 were considered to be significant.results: frequency of t/t and c/t genotypes in comparison to c/c genotype was increased in professional karatekas and amateur karatekas versus to control volunteer (odd ratio > 1) however, was not significant. odd ratios of t/t and t/c genotypes compared to c/c in professional group versus controls were 1.125 (95%ci: 0.556 2.275) and 1.034 (0.538 1.984), respectively. also, odd ratio of t/t and t/c in amateur group versus controls were 1.002 (0.535 1.876) and 1.256 (0.715 2.205), respectively.conclusion: the igfi gene c/t polymorphism is not significantly associated with the physical performance acute;s levels of karatekas athletes in iranian population.