The Effect of Eight-Week Aerobic Exercises on Vascular Cellular Adhesion Molecule-1, Intracellular Adhesion Molecule and Body Composition of Addicts Treated with Methadone

Background: drug consumption and addiction lead to serious cardiovasculardiseases as well as inflammation. cellular adhesion molecules are glycoproteinsthat mediate a leukocyte reaction to inflammation. this study aims to determinethe effect of aerobic exercises on some cardiovascular factors in addicts treatedwith methadone.methods: this is a semi-experimental research. to conduct this research, 30male addicted patients treated with methadone with a mean age of 33.53±15.42years, 70.06±15.42kg weight and 174.8±5.69cm were selected after medicalscreening and randomly divided into experimental (n=16) and control (n=16)groups. first, the height, weight and body mass index (bmi) of participantsin both groups were measured. blood samples were taken from the subjects inorder to measure the intercellular adhesion molecules 1 (sicam) and cellularvascular adhesion 1 (svcam) in serum. the experimental group had an aerobicexercise program including use of a treadmill with a 40 to 50% maximum heartrate in the beginning and then, a 70 to 80% maximum heart rate. the controlgroup had only a follow-up. after 8 weeks, all variables were measured in bothgroups. correlated t-test and independent t-test were used for intragroup andintergroup comparisons (p<0.05).results: results showed that after 8 weeks aerobic exercises, there was nosignificant difference in icam-1 (p=0.397), vcam-1 (p=0.521), and bmi(p=0.223).conclusion: although 8-weeks aerobic exercise was not effective and sufficientfor bmi, icam-1 and vcam-1 indicators of the addicts treated with methadone,but it reduced icam-1 and vcam-1 in the exercise group.