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   Single Nucleotide Polymorphism of the Interferon-Γ Gene (Ifn-Γ +874 T/A) and the Prognosis of Hepatitis B Infection  
   
نویسنده Naghizadeh Mohammad Sadegh ,Naseri Mohsen ,Fereyduni Mohammad ,Ziaee Masoud ,Tane Abdolghader ,Safari Hamidreza ,Mahavar Neda ,Mahdavi Roya ,Anani Sarab Gholamreza
منبع Journal Of Medical Microbiology And Infectious Diseases - 2018 - دوره : 6 - شماره : 2,3 - صفحه:43 -47
چکیده    Introduction: chronic hepatitis b virus infection is a multifactorial disease with a variety of clinical outcomes. since interferon-gamma (ifn-γ) is a significant immune factor in antiviral defense, this case-control study aimed to investigate the potential relationship between single nucleotide polymorphism of rs2430561 and hepatitis b infection outcome in a population of birjand city, eastern iran. methods: blood samples were collected from 60 chronically hbv- infected patients and 60 healthy subjects with the history of hbv infection. genomic dna was extracted from whole blood by the salting-out method. the first intron of ifn-γ with a length of 264 bp was amplified by amplification refractory mutation system polymerase chain reaction (arms-pcr) followed by sequencing. results: our results exhibited a statistically significant difference between patients and control individuals (p-value<0.001). the frequency of the allele a was 73.3% in hbv- infected patients, whereas in controls (individuals with a history of hbv infection) it was 46.7%. conclusion: a statistically significant relationship was found between the ifn-γ (+874t/a, rs2430561) single nucleotide polymorphism (snp) and chronic hbv infection in the studied population. the obtained results showed that hbv infected individuals with t allele have less risk of progressing to chronic hbv infection. it also suggests that the homozygous carriers of the a allele are more vulnerable to chronic hbv infection.
کلیدواژه Chronic Hepatitis B ,Single Nucleotide Polymorphism ,Iran
آدرس Birjand University Of Medical Sciences, Student Research Committee, ایران, Birjand University Of Medical Sciences, Cellular And Molecular Research Center, ایران, Birjand University Of Medical Sciences, Cellular And Molecular Research Center, ایران, Birjand University Of Medical Sciences, Infectious Diseases Research Center, ایران, Birjand University Of Medical Sciences, Student Research Committee, ایران, Birjand University Of Medical Sciences, Student Research Committee, ایران, Birjand University Of Medical Sciences, Student Research Committee, ایران, Birjand University Of Medical Sciences, Department Of Immunology, ایران, Birjand University Of Medical Sciences, Cellular And Molecular Research Center, ایران
پست الکترونیکی ghansa@yahoo.com
 
 

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