|
|
|
|
Hepatoprotective Activity of Silver Nanoparticles Synthesized Using Aqueous Leaf Extract of Punica Granatum Against Induced Hepatotoxicity in Rats
|
|
|
|
|
|
|
|
نویسنده
|
Kumar Manoj ,Ranjan Rakesh ,Kumar Amar ,Sinha Manoranjan Prasad ,Srivastava Rohit ,Subarna Sweta ,Kumar Mandal Samir
|
|
منبع
|
يافته هاي نوين در علوم زيستي - 2021 - دوره : 7 - شماره : 4 - صفحه:381 -389
|
|
|
|
|
چکیده
|
Punica granatum leaf extracts have been used since time immemorial in traditional medicines. it is used for its antioxidant properties. green nanoparticle synthesis is an emerging field which has opened an entirely different scope for medicinal formulations. it has been reported by many users that the green nanoparticles are more effective medicines as compared with their simple extracts. thus, in order to evaluate these speculations, the present work was undertaken to assess the hepatoprotective activity of silver nanoparticles synthesized using aqueous leaf extract of punica granatum in comparison with the aqueous extract. after ccl4 intoxication the serum bilirubin total increased significantly (p<0.05) and the total protein level decreased significantly (p<0.05) as compared with the control group; in addition, alkaline phosphatase activity, aspartate aminotransferase activity and alanine transaminase activity increased significantly (p<0.05). the ccl4 intoxicated rats were treated with aqueous leaf extract and synthesized nanoparticles, the results clearly revealed that the aqueous extract of punica granatum showed hepatoprotective effect, as the liver profile altered by ccl4 toxicity, recovered to normal control values. moreover, the nanoparticles synthesized using aqueous leaf extract of punica granatum were comparatively more effective as hepatoprotective agent than the aqueous extract of punica granatum.
|
|
کلیدواژه
|
Alp ,Alt ,Ast ,Bilirubin ,Ccl4 ,Liver Profile ,Total Protein ,Alp ,Alt ,Ast ,Ccl4
|
|
آدرس
|
Ranchi University, Xavier’S College, Department Of Zoology, India, Ranchi University, Department Of Zoology, India, Ranchi University, Department Of Zoology, India, Ranchi University, Department Of Zoology, India, Ranchi University, Department Of Zoology, India, Ranchi University, Department Of Zoology, India, Ranchi University, Department Of Zoology, India
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hepatoprotective activity of Silver Nanoparticles synthesized using aqueous leaf extract of Punica granatum against induced hepatotoxicity in rats
|
|
|
|
|
Authors
|
Kumar Amar ,Kumar Manoj ,Sinha Manoranjan Prasad ,Ranjan Rakesh ,Srivastava Rohit ,Kumar Mandal Samir ,Subarna Sweta
|
|
Abstract
|
Punica granatum leaf extracts have been used since time immemorial in traditional medicines. It is used for its antioxidant properties. Green nanoparticle synthesis is an emerging field which has opened an entirely different scope for medicinal formulations. It has been reported by many users that the green nanoparticles are more effective medicines as compared with their simple extracts. Thus, in order to evaluate these speculations, the present work was undertaken to assess the hepatoprotective activity of silver nanoparticles synthesized using aqueous leaf extract of Punica granatum in comparison with the aqueous extract. After CCl4 intoxication the serum bilirubin total increased significantly (p<0.05) and the total protein level decreased significantly (p<0.05) as compared with the control group; in addition, alkaline phosphatase activity, aspartate aminotransferase activity and alanine transaminase activity increased significantly (p<0.05). The CCl4 intoxicated rats were treated with aqueous leaf extract and synthesized nanoparticles, the results clearly revealed that the aqueous extract of Punica granatum showed hepatoprotective effect, as the liver profile altered by CCl4 toxicity, recovered to normal control values. Moreover, the nanoparticles synthesized using aqueous leaf extract of Punica granatum were comparatively more effective as hepatoprotective agent than the aqueous extract of Punica granatum.
|
|
Keywords
|
ALP ,ALT ,AST ,bilirubin ,CCl4 ,liver profile ,total protein ,ALP ,ALT ,AST ,CCl4
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|