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   assessment of membrane stability, central nervous system depressant, and gut motility effects of lablab purpureus seeds  
   
نویسنده roy joysree ,bhowmik sutapa ,uddin md. giash ,hasan md. nazmul ,al-maswood abdullah ,zahan sumyya ,abdul aziz md. ,hossain md. farhad ,hossain mohammed kamrul ,islam mohammad safiqul
منبع journal of herbmed pharmacology - 2022 - دوره : 11 - شماره : 2 - صفحه:238 -244
چکیده    Introduction: lablab purpureus, under the family of fabaceae, is a plant with various pharmacological activities. the present study was aimed to investigate the phytoconstituents, membrane stabilizing activity, central nervous system (cns) depressant potential, and gastrointestinal (gi) motility of the methanol extract of l. purpureus seeds (melps). methods: the methanol plant extract was screened for different phytochemical groups. mice were classified into four groups for in vivo activities. group-i was designated as negative control and received distilled water (10 ml/kg body weight); group-ii served as positive control and received diazepam (1 mg/kg body weight). group-iii and group-iv both were experimental groups and received plant extract at 200 and 400 mg/kg body weight, respectively. results: alkaloids, carbohydrates, saponins, glycosides, tannins, phenols, flavonoids, and proteins were found after phytochemical analysis. on hypotonic solution-induced hemolysis of erythrocyte membrane, melps9 (9 mg/ml) resulted in the highest percentage of inhibition (60.51 ± 0.889), and on heat-induced hemolysis, melps9 (9 mg/ml) resulted in the highest percentage of inhibition (33.97 ± 0.21). in the case of the cns depressant potential experiment, mice that received a sample at a dose of 400 mg/kg body weight showed the highest result (54.40 ± 4.51) compared with the positive control (14.2 ± 3.70) (p < 0.001). similarly, 400 mg/kg dose sample exhibited the highest percentage of inhibition (60.51 ± 0.889) of hemolysis and gi motility (22.26%). conclusion: it can be concluded that the melps has potential membrane stability, cns depressant, and antimotility effects.
کلیدواژه lablab purpureus ,antidepressant ,membrane stability ,gastrointestinal motility
آدرس noakhali science and technology university, faculty of science, department of pharmacy, bangladesh, noakhali science and technology university, faculty of science, department of microbiology, bangladesh, university of chittagong, faculty of biological sciences, department of pharmacy, bangladesh, university of chittagong, faculty of biological sciences, department of pharmacy, bangladesh, noakhali science and technology university, faculty of science, department of pharmacy, bangladesh, university of chittagong, faculty of biological sciences, department of pharmacy, bangladesh, noakhali science and technology university, faculty of science, department of pharmacy, bangladesh, graduate school of inje university, department of physical therapy, south korea, university of chittagong, faculty of biological sciences, department of pharmacy, bangladesh, noakhali science and technology university, faculty of science, department of pharmacy, bangladesh
پست الکترونیکی research_safiq@yahoo.com
 
     
   
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