antidiabetic activity of tannin fraction of bridelia ferruginea (benth) leaf extract on fructose-induced diabetic mice

introduction: bridelia ferruginea is a plant known for its antidiabetic properties. however, few studies on leaf extracts have induced anti-hyperglycemic activity on normal mice subjected to carbohydrate overload. the current study was designed to assess the effect of the leaf extracts’ fraction on fructose-induced diabetic mice. methods: the in vitro ferric-reducing antioxidant power (frap) assay were carried out and the condensed tannins quantified. the vanillin-hcl method was used to characterize the condensed tannins. the antidiabetic effect on fructose-induced diabetic mice was evaluated for 28 days using a fructose-enriched fat diet approach. results: the fraction confirmed the antioxidant activity with a reducing power of 800 μg/ml comparable to ascorbic acid at 200 μg/ml. the condensed tannins were estimated at 79.6 ± 3.4 mg catechin equivalent per gram of sample. significant decreases in blood sugar levels of 6.25% at the 7^th day, 11.04% at the 14^th day, 12.61% at the 21^th day, and 11.35% at the 28^th day were obtained in mice treated with the extract dose of 200 mg/kg of body weight, compared to the positive control group. the decreases of 37.11% of triglycerides and 40.16% of total cholesterol were also obtained. conclusion: the investigated fraction showed notable antidiabetic activity and might be a good candidate in the treatment of diabetes.