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   the effects of aqueous extract of origanum vulgare on learning and memory in male rats  
   
نویسنده ghaderi ahvan ,karimi asaad ,talaei fahimeh ,shahidi siamak ,faraji nafiseh ,komaki alireza ,komaki alireza
منبع journal of herbmed pharmacology - 2020 - دوره : 9 - شماره : 3 - صفحه:239 -244
چکیده    Introduction: the effectiveness of antioxidants on learning and memory improvement has been shown, previously. due to the high level of antioxidants, available in origanum vulgare, the present experiment aimed to examine the effect of aqueous extract of o. vulgare on passive avoidance learning (pal) in male wistar rats. methods: this study was performed on 30 male wistar rats weighing 250 to 290 g. the rats were randomly assigned into five groups (n=6), as follows: the control, sham (saline), and three groups treated with different doses of o. vulgare extract (150, 250, and 350 mg/kg). the saline or extract was administered via daily oral gavage for 14 days. the groups were then subjected to the passive avoidance task, and their behaviors were recorded. the rats’ locomotor activity was also measured using the open field test. results: the number of trials to acquisition was significantly lower in the “o. vulgare (350 mg/kg)” group than the control group. the step-through latency and the time spent in the dark compartment in the retention test, was significantly higher and lower in the “o. vulgare (250 and 350 mg/kg)” groups than the control group, respectively. no significant differences were found in the distances traveled among the experimental groups in the open field test. conclusion: aqueous extract of o. vulgare can enhance learning and memory. the high levels of antioxidants in o. vulgare extract may be responsible for its effectiveness in learning and memory.
کلیدواژه medicinal plant ,avoidance learning ,origanum vulgare ,anti-oxidants ,locomotor activity
آدرس hamadan university of medical sciences, neurophysiology research center, iran, hamadan university of medical sciences, neurophysiology research center, school of advanced technologies in medicine, department of neuroscience, iran, hamadan university of medical sciences, neurophysiology research center, iran, hamadan university of medical sciences, neurophysiology research center, school of advanced technologies in medicine, department of neuroscience, iran, hamadan university of medical sciences, neurophysiology research center, iran, hamadan university of medical sciences, neurophysiology research center, school of advanced technologies in medicine, department of neuroscience, iran, hamadan university of medical sciences, neurophysiology research center, school of advanced technologies in medicine, department of neuroscience, iran
پست الکترونیکی alirezakomaki@gmail.com; komaki@umsha.ac.ir
 
     
   
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