preventive effects of allium hirtifolium boiss methanolic and aqueous extracts on renal injury induced by lead in rats

Introduction: in this study the kidney protective effects of methanolic and aqueous extracts of allium hirtifolium boiss (shallot) were evaluated on kidney toxicity induced by lead (pb) in wistar rats. methods: eighty adult female wistar rats of 3–5 months of age and weighing 200–250 g were allocated randomly into 10 groups and treated for 15 and 30 days as follows: control group, pb (10 mg/l), methanolic extract of shallot (12.5 mg/kg and 25 mg/kg), pb plus methanolic extract of shallot (12.5 mg/kg and 25 mg/kg), aqueous extract of shallot (12.5 mg/kg and 25 mg/kg), pb plus aqueous extract of shallot (12.5 mg/kg and 25 mg/kg). serum concentrations of glucose as well as renal parameters were measured at 15 days and 30 days in the studied groups. results: analysis showed a significant reduction in the mean of urea in the methanolic extract group with a concentration of 12.5 mg/kg, compared to the lead group. consumption of 25 mg/kg methanolic extract of shallot showed a significantly reduction of uric acid, creatinine and total protein in comparison with control group and lead group. consumption of 25 mg/kg methanolic extract of shallot+lead was able to reduce the mean of urea uric acid, creatinine and total protein in comparison with lead group. also, the results showed that methanolic extract of shallot+lead at a dose of 12.5 mg/kg could reduce the mean of urea uric acid, creatinine and total protein in comparison with lead group. there was no significant difference in the rest groups. conclusion: the results of the study showed that shallot extract can dose dependently reduce the factors related to lead induced renal damages.