analysis of crp, vitamin d and metabolic factors in non-obese patients with polycystic ovary syndrome: a cross sectional study in imam khomeini hospital, ahvaz

Women of childbearing age which is associated with increased risk of metabolic complications, including cardiovascular disease. increasing c-reactive protein (crp) as an inflammatory factor is common in these patients. in addition, vitamin d deficiency is quite common among females with pcos. the aim of this study is to determine the relationship of crp levels with vitamin d and metabolic factors in non-obese patients with pcos. materials and methods: this experimental study was done on 100 non-obese 20-40 years old females (bmi<30) who were diagnosed with pcos. based on crp levels, the females are categorized in two groups (normal crp<0.8 mg/dl). the serum levels of homa-irc, fbs, hdl-c, ldl-chl, vitamin d and crp of participants in the study were measured. then, collected data was analyzed through the spss software (version. 23). in all analysis, the p-value is presumed to be less than 0.05. results: the mean age of patients was 27.11±6.25. patients in high crp group, had significantly lower levels of hdl-c and higher triglyceride (tg) compared to controls. in addition, the increase in crp was associated with vitamin d deficiency. this was while no significant difference between the two groups of patients were observed in terms of insulin resistance. conclusions: the findings of present study suggest that higher crp levels are positively correlated with vitamin d and hdl-c deficiency as well as an increased tg levels in non-obese females with pcos. these findings have significant implications for the understanding of how vitamin d deficiency can contribute to inflammatory and metabolic responses in patients with pcos. a future study could assess the long-term implications of vitamin d supplementation on inflammation and metabolic outcome of patients with pcos.