blood lipidomic and breast cancer risk: protocol of a systematic review

Background and objectives: breast cancer is the most common type of cancer and the leading cause of death in women worldwide. early detection of breast cancer by measuring metabolites that can be easily detected through blood tests will significantly help in time treatment, prevent cancer progression, and reduce the risk of death in breast cancer patients. one of the constant metabolic characteristics of cancer is lipidomic remodeling, which includes changes in fatty acid transport, lipogenesis, lipid storage, and beta-oxidation to supply energy. this review aims to compare lipid changes between women with and without breast cancer.materials and methods: the systematic review will search and summarize data on observational studies from medline/pubmed, scopus, embase, and web of science databases and grey literature published between january 2000 and january 2025. keywords related to ’breast cancer’ and ’lipidomic’ will be used to retrieve relevant documents. the pecos model will be used to include eligible studies. the protocol of this systematic review follows the prisma-p statement.results and conclusion: this systematic review will help summarize the existing evidence about the use of blood lipids in breast cancer diagnosis and prognosis and recognize the current gaps in research to design further high-quality studies with the ultimate goal of easy and early detection of breast cancer.