effects of eight weeks of resistance training and consumption of pomegranate on glp-1, dpp-4 and glycemic statuses in women with type 2 diabetes: a randomized controlled trial

Background and objectives: diabetes is one of the metabolic diseases with a significant increase rate in recent decades. the aim of this study was to investigate effects of eight weeks of resistance training and consumption of pomegranate juice on glucagon-like peptide-1(glp-1), dipeptidyl peptidase 4(dpp-4) and glycemic statuses in women with type 2 diabetes (a randomized controlled trial). materials and methods: samples included 40 women with type 2 diabetic aged 45–55 years, who were randomly selected and divided into four major groups of control (n = 10), resistance training (n = 10), pomegranate juice consumption (n = 10) and resistance training and pomegranate juice consumption (n = 10) groups. resistance training group and resistance training and pomegranate juice consumption group carried out three resistance training sessions for eight weeks, each week with a maximum intensity of 30%. by the end of the week 18, groups reached 80% of the maximum repetition. the pomegranate juice group received 100 ml of pomegranate juice every day. analysis of variance (anova) was carried out using spss software v.21. results: results showed that eight weeks of resistance training with pomegranate juice consumption significantly increased glp-1, hdl, insulin (p = 0.0001) and decreased dpp-4, ldl and glucose (p = 0.0001) levels in women with type 2 diabetes. furthermore, results showed that resistance training significantly increased glp-1 and decreased ddp-4 levels in these women. no significant changes were seen in control group and pomegranate juice consumption in the study variables. conclusions: based on the results of this study, resistance training with consumption of pomegranate juice effectively improves insulin secretion and glycemic control. this improvement can be attributed to increases in glp-1 and ddp-4 levels.