drug infused al2o3‑bioactiveglass coatings toward the cure of orthopedic infection

A unique implant coated substrate with dual-drug-eluting system exhibiting antibacterial, anti-inflammatory, and bone regenerative capacity has been fabricated using spray pyrolysis deposition (spd) method. bioglass (bg) and bg-alumina (bg-al) composites coatings with different concentrations of al incorporated on bg network over the cp-ti substrate were fabricated using spd technique. phase purity of bg and bg-al composites were analyzed by xrd in which na2ca2si3o9 and β-na2ca4(po4)2sio4) and na7.15(al7.2si8.8o32) phases were formed. surface morphology of the coated substrates was analyzed by sem. uniformity of the coatings were evaluated by surface profilometer and the uniform distribution the nano- particles were confirmed with elemental mapping. systematically, each apatite layer formation on coated substrate was con- firmed by immersing the samples for 1, 3, and 7 days in simulated body fluid and the needle-like structure was characterized using sem. cumulative release of tetracycline hydrochloride (tet) antibiotic and dexamethasone (dex) anti-inflammatory drug-loaded bg-al and bg-al composite-coated substrate were studied for 24 h. antibacterial activity of the coated sub- strates were evaluated by time-dependent growth inhibition and minimal inhibitory concentration (mic) assays in which bg-al and bg-al composite loaded with tet showed considerable growth inhibition against s. aureus. osteoblast-like cells (mg-63) exhibited profound proliferation with no cytotoxic effects which was due to release of dex drug-coated substrates. thus, surface modification of cp-ti substrate with bg, bg-al composites coatings loaded with tet and dex drug can be considered for post-operative orthopedic implant infection application.