Investigation of the effects of resveratrol on total oxidant/antioxidant capacity on experimentalcigarette smoking model

Objective the harmful effects of smoking on body are known to be caused by oxidative stress in tissues. with the many harmful substances in smoke it serve as a good model of free radical damage could be monitored. the agents preventing free radical induced oxidation, capable of trapping and stabilizing free radicals are called ‘antioxidants”. resveratrol is a powerful antioxidant that has anti-inflammatory, analgesic and osteogenic effects. in this study we evaluated the effects of smoking and resveratrol on oxidative stress. material-method for 4 weeks rats were inhalated cigarette smoke (6 cigarette/ day) and after that time 20 mg/kg/day resveratrol was given via oral gavage during 28 days together with cigarette smoke. at the end of 8 weeks total exposure to cigarette smoke, rats were sacrified and bloods and tongue samples were collected. biochemically serum and tissue total antioxidant / oxidant capacity (tac / toc) were evaluated. results there were no statistical difference between groups in terms of tac and toc serum. tac tongue is higher in cigarette+resveratrol and cigarette groups. discussion in the experiment performed with 6 cigarettes per day for 8 weeks, toxic effect of cigarette induced antioxidant system in the organism to protect the body and that is more effective than antioxidant effect of resveratrol.