Theeffect of melatonin on periodontal bone destructionand oxidative stres parameters in experimental periodontitis

The purpose of this study was to evaluate the effect of melatonin on periodontal bone destruction and serum malondialdehyde (mda), superoxidedismutase (sod), glutathione peroxidase (gsh–px) and determine the level of gingival melatonin in experimental rat periodontitis. his study, 30 wistar albino male rats were used. rats were divided into 4 groups as healty(s) saline solution(s), smelatonin(m), periodontitis(p)s and pm. rat tissue sampleswereobtained for histomorphometric and histopathologic evaluation. serum samples were collected in order to determine levels of mda, sod, gsh–px and melatonin. however melatonin levels were evaluated in gingival tissue of the rats. ps and pm groups were similar in histopathological and histomorphometric evaluation. however pmnldensity in pm group was lower than ps group. in p group, sod and gsh–px, levels were lover and mda levels were higher when compared with s group. melatonin was led to a decrease in mda levels and an increase sod and gsh–px levels. gingival melatonin levels were determined significantly lower in ps group. our study supported that melatonin, by virtue of its ability to directly scavenge rot,to indirectly stimulate antioxidant enzymes and also with the decrease in its tissue concentration levels during inflammation; melatonin may reduce oxidative stress and associated damage in experimental periodontitis.