Effect of visfatin and il-6 on nonalcholic fattyliver disease in mouse

Nonalcoholic fatty liver disease has recently gained increasing importance as the most common of liver disorders. nafld comprises a spectrum of chronic liver diseases, starting from a simple fatty liver which may progress to steatohepatitis, fibrosis and cirrhosis. the link between obesity, insulin resistance and nafld and its more severe from called nonalcoholic steatohepatitis (nash) remain as the major focus of investigation to enlighten the pathogenesis and the treatment of the disease. adipokines which are secreted from adipose tissues increases with the body mass. most adipokines increased in the fattyliver but changes in the levels of visfatin and il-6 remains controversial. we aimed to investigate role of visfatin and il-6 in nafld. 29 swiss mice used in experiment divided as one control (8 mice) and one experiment (21 mice) groups. all animal had free access to food. control animals were fed with tap water while experiment groups were fed with 30% fructose solution for 4, 5 and 6 weeks respectively. at the end of feeding period animals were sacrificed, liver, fat and blood tissues were taken for histological and biochemical analysis. statistically meaningful differences were found between control and experiment groups in histological scores, blood alp, ast, t.chol and glucose levels. increased visfatin and il-6 staining observed in ihc sections of fat and liver tissues so it is concluded that visfatin and il-6 levels were increased with fat gain. it could be concluded that high fructose diet caused serious damage and lipogenesis accompanied by visfatin and il-6 increase in mice. our study may be helpful to further studies related with liver lipogenesis and adipokines.