Oxytocin Effect on Sepsis-induced Experimental Rat Renal Failure Model: A Histological and Biochemical study

Objective: we aimed to investigate the therapeutic role of oxytocin (ot) in sepsis induced rats and its effects on kidneys. sepsis was induced in 24 of them by cecal ligation-perforation (clp) method. material-method: one of the groups of clp did not recieve any treatment while either saline 1 ml/kg or ot 0.4 mg/kg was applied intraperitoneally to the other groups within the first hour of surgery. 8 rats were sham-operated and 8 rats were spared as control group. plasma tnf-α α (tumor necrosis factor- α), crp (c reactive protein), mda (malondialdehyde) levels, total antioxidant capacity (tac), creatinine level and peripheral leukocyte (wbc) counts were measured. results: tnf-α, crp, mda, tac levels and wbc counts were significantly increased in clp and clp-saline groups, on the contrary they are decreased in clp-ot group. histopathologically loss of brush border, tubular dilatation and mononuclear cell infiltration was significantly decreased in clp-ot group but there was no significant difference in erytrocyte extravasation and cast formation when compared to clp and clp-saline groups. conclusions: our results indicate that ot may have a therapeutic value in limiting sepsis induced inflammation and organ damage.