cardio- and hepatoprotective effects of hydrogen sulfide in a high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats

Background: hydrogen sulfide (h2 s) is the third most crucial gas that is produced inside the body, and at physiological levels, it increases a wide range of health properties, such as anti-inflammatory antioxidant effects. objectives: this study aimed at evaluating the impact of h2 s administration on oxidative stress (os) in the heart and liver tissues of diabetic rats. methods: twenty-eight wistar rats were randomly divided into 4 groups, namely, the healthy control group, the diabetic group, and diabetic groups treated with 50 µm/kg and 100 µm/kg of h2 s. after 60 days of treatment, the animals were sacrificed, and biochemical and os markers were determined using colorimeter methods. in addition, the liver tissue underwent histological assessment. results: the findings revealed that h2 s controlled the weight of rats and significantly decreased fasting blood sugar (fbs) in the treatment group with a dose of 50 µm/kg and 100 µm/kg (p<0.05) compared to the diabetic animals. further, insulin concentration and insulin resistance in the h2 s 100 µm/kg group decreased in comparison to the diabetic group (p<0.05). the levels of triglyceride, cholesterol, atherogenic index, and low-density lipoprotein in h2 s-treated animals were markedly lower than in the diabetic group (p<0.05). the results of os parameters demonstrated that h2 s 100 µm/kg reduced the malondialdehyde in the heart tissue compared to the diabetic group (p<0.05). the histological assessment also confirmed the effectiveness of h2 s in improving liver morphology and parenchymal structure. conclusion: according to the results of this study, h2 s can be considered a suitable therapeutic agent to prevent diabetes complications.