angiotensinogen gene m235t and t174m polymorphisms in diabetic nephropathy in a bangladeshi population

Background: marker gene polymorphisms linked with the renin-angiotensin-aldosterone system (raas) have been broadly studied in diabetic nephropathy (dn) patients considering that raas is a potential drug target to slow down kidney disease progression. objectives: the aim of the present study was to determine the link between m235t and t174m variants of angiotensinogen (agt) gene and dn. methods: a total of 93 patients with dn, mean age of 56±8 years, systolic blood pressure (sbp) of 141±14, and diastolic blood pressure (dbp) of 84±7 mm hg (mean±sd) were investigated, among whom 59 patients had a family history of type 2 diabetes mellitus. a total of 96 healthy subjects served as the control group with no family history of diabetic nephropathy (fhdn) and type 2 diabetes mellitus, a mean age of 47±10 years, sbp of 126±11, and dbp of 76±6 mm hg. pcr–restriction fragment length polymorphism was employed for genotyping m235t and t174m molecular variants. results: genotype frequencies of the variants m235t (χ2=2.038, p=0.361) and t174m (χ2=2.952, p=0.229) did not show any statistically significant association with type 2 diabetic nephropathy (t2dn) compared to the control. based on fhdn and family history of diabetes mellitus (fhdm), the frequency of genotypes of m235t marker (p=0.360) in fhdn, and (p=0.886) fhdm; t174m marker (p=0.641) in fhdn, and (p=0.425) fhdm also did not show any statistically significant association with t2dn compared to the controls. conclusion: m235t and t174m variants were not associated with dn in a bangladeshi population.