cardiovascular property of resistance training with an emphasis on pi3k/akt1 genes expression in type 2 diabetic rats

Background: the potential role of exercise in physiological cardiac hypertrophy is rooted in both hormonal and genetic components. objectives: the aim of this study was to determine the impact of resistance exercise on the expression of pi3k and akt1 in cardiac tissue of type 2 diabetes (t2d) rats and their physiological cardiac hypertrophy. methods: first, 21 male wistar rats (220±20 g) were obese with 6-week high-fat diet (hfd) and were randomly assigned into non-diabetes, control t2d, and exercise diabetes groups. after inducing obesity, t2d was induced by intraperitoneal injection of streptozotocin (25 mg/kg) for diabetes groups. rats in the exercise group completed a 6-week resistance exercise program, 5 sessions per week. pi3k/akt1 expression and the weight ratio of left ventricular to heart, heart to body, and left ventricular to body were compared by analysis of variance (anova) between groups. results: in response to the induction of diabetes, the expression of pi3k/akt1 in heart tissue decreased significantly compared to that of non-diabetic rats (p=0.001 and p=0.001, respectively). further, resistance training led to a significant increase in pi3k expression (p=0.028) and akt1 (p=0.032) and the weight ratio of left ventricular to heart (p=0.001), heart to the body (p=0.001), and left ventricular to the body (p=0.001) compared to control diabetic rats. conclusion: resistance training is associated with physiological cardiac hypertrophy in diabetic rats, and this improvement may be attributed to the pi3k/akt1 signaling pathway.