synthesis and in vitro antibacterial evaluation of schiff bases derived from 2-chloro-3-quinolinecarboxaldehyde

Background: design, identification, and synthesis of new antimicrobial agents along with preventive proceedings are essential to confront antibiotic-resistant pathogenic bacteria. heterocyclic schiff bases are biologically important compounds whose antimicrobial potentials have been proven to bacterial and fungal pathogens. objectives: in this study, some quinoline schiff bases were synthesized from condensation of 2-chloro- 3-quinolinecarboxaldehyde and aniline derivatives. their inhibitory activities were evaluated against 6 gram-positive and 2 gram-negative bacterial pathogens. methods: disc diffusion, broth microdilution, and time-kill tests were applied according to the clsi guidelines to determine izd, mic, and mbc values. results: 2-chloro-3-quinolinecarboxaldehyde schiff bases could inhibit the growth of bacteria with izds of 7.5-19.8 mm, mics of 256-2048 μg ml-1, and mbcs of 512 to ≥2048 μg ml-1. conclusion: moderate antibacterial effects were observed with heterocyclic schiff bases. complexation and structural changes can improve their antimicrobial properties.