a short review on angptl-8 as an important regulator in diabetes

Angptl8, a new hormone, is regarded as a novel target for type-2 diabetes and associated metabolic disorder. nutritional state and hormonal factors are involved in the regulation of angptl-8 expression. this protein is associated with some myokines or adipokines. several studies confirmed the function of angptl-8 in glucose metabolism and diabetes complications; however, there are opposite results. the accurate function of angptl-8 in t2d remains unclear. further strictly controlled studies including measuring methods, nutritional state, diagnostic criteria of overweight/obesity, age, and ethnicity may help to resolve discrepancies. in addition, more studies are demanded to clarify the potential role of angptl-8 in humans, a cause or an effect of this protein in association with insulin resistance, the regulatory mechanism of angptl-8 expression, and the association of angptl8 with other adipokines or myokines. in this mini review, we described various roles of angptl-8 in diabetes.