Improved Glucose and Il-6 By Aerobic Training Despite No Change in Insulin and Insulin Resistance in Obese Women

Background: regular physical activity is recognized as a non-pharmacological treatment of inflammation and glycemic profile. objectives: this exercise aimed to determine the effect of aerobic training on serum interleukin-6 (il-6), glucose and insulin resistance in obese females. patients and methods: thirty-two middle-aged obese women (body mass index [bmi], 32 ± 3 kg/m2) aged 35 to 45 years were randomly assigned to exercise (aerobic training, n=16) and control (n=16) groups. exercise subjects were completed a 12 weeks aerobic training program as 3 sessions per week at 60%-80% of hrmax and control subjects received no training. pre- and post-training of fasting serum il-6, insulin, insulin resistance, and glucose concentration were measured and compared between 2 groups. results were compared using t test at a significance level of p<0.05. results: exercise group obtained significant decreases in bmi, body fat %, and abdominal obesity as well as the concentrations of serum il-6 and fasting glucose (p < 0.05). no significant difference was observed between pre- and post-training of insulin and insulin resistance in the exercise group (p > 0.05). there were no alterations in these variables in the control group (p > 0.05). conclusions: these data suggest that aerobic training may improve glycemic profile in absence of change in insulin resistance of women with abdominal obesity.