the assessment of 25-hydroxy vitamin d serum level in asthmatic patients: a case-control study

Background: the prevalence of vitamin d deficiency is increasing due to changes in lifestyle and dietary habits. the aim of this study was to compare the serum levels of 25hydroxy vitamin d between patients with bronchial asthma and the healthy control group. patients and methods: in this casecontrol study, 45 patients with asthma and 45 healthy subjects were enrolled and the level of serum 25 (oh) vitamin d was measured in both groups. in addition, a welltrained observer assessed airway reversibility, peak flowmetry and spirometry in the participants. the data were statistically analyzed using t test, oneway analysis of variance (anova), and chisquare test with stata software (version 11). results: the mean age (±sd) of participants were 49.06 ±16.43 and 46.13 ±16.10 years in case and control groups, respectively (p=.394). the prevalence of vitamin d deficiency was high in both groups (69% in case and 65.5% in control groups). the mean (±sd) serum 25 (oh) vitamin d was 16.24 (±14.98) ng/ml in case group and 17.70 (±16.07) ng/ml in control group (p=.657). we found a positive correlation between the levels of vitamin d and the amount of fev1 (r=0.2). conclusions: according to the present study, the mean serum levels of vitamin d differences were not statistically significant between asthmatic patients and control group. however, the results of this study showed a positive relationship between forced expiratory volumes in first second (fev1) and vitamin d levels