Adiponectin/TNF-α Ratio Following a Selected Aerobic Training in Sedentary Adult Obese Men

Background: based on clinical studies, low adiponectin and high tumor necrosis factor alpha (tnf-α) are associated with obesity and related diseases such as type 2 diabetes and insulin resistance. objectives: in this study, we aimed to investigate the effect of an aerobic training program on adiponectin, tnf-α, and adiponectin/tnf-α ratio in adult obese men. patients and methods: for this purpose, 24 sedentary adult obese men matched for age (38 ± 3.23 years) and body mass index (31.94 ± 3.26 kg/m2) were selected and divided into exercise (aerobic training) and control groups. exercise subjects participated in an aerobic exercise training intervention for 12 weeks (3 times/week) and the control group did not participate in aerobic intervention. anthropometric and biochemical data including fasting serum adiponectin, tnf-α, and adiponectin/tnf-α ratio were measured before and after aerobic training for each participant in each group. data were analyzed by both independent and paired sample t test. results: compared to pre-training, fasting serum adiponectin decreased significantly (p = .019), but serum tnf-α was not changed by aerobic training (p = .057). a significant increase was observed in adiponectin/tnf-α ratio in exercise subjects after aerobic training (p = .008). conclusions: based on these data, we conclude that aerobic training intervention is associated with improved inflammatory profile in obese subjects.