ROLE OF NITRIC OXIDE IN INFLAMMATORY PERIODONTAL DISEASES: A REVIEW

Nitric oxide (no) is a unique molecule for biological organisms, and has also very important effects on various pathologic and physiologic mechanisms. many cell types can generate no during different pathological and physiologic conditions. recently, many authors have been reported the connections between no and inflammatory diseases. periodontal pathologies are characterized with specific periodontal inflammation and host tissues damage around the teeth, and additional factors such as force application on teeth. however, the production of no and the role of no in the development of periodontal pathologies are unclear. on the other hand, many evidences from previous studies indicates a close relationship between no and periodontal pathologies. in this review, we want to discuss; overproduction of no during inflammation and mechanical stress of force application on teeth, which directly cause progression of periodontal pathologies, and the possible effects of no overproduction in periodontal diseases.