CYTOTOXICITY OF DENTAL RESIN COMPOSITES: AN IN VITRO STUDY

Objective: the objective of this in vitro study was to evaluate the cytotoxic effects of two different resin based restorative meterials (clearfil majesty® ve grandio flow®) on human fibroblast cells via mtt [3-(4,5dimethylthiazol-2)-2,5 diphenyltetrazolium bromide] test. material and methods: fibroblast cells derived from human amniotic fluid were used in this study. the samples prepared in 2 mm height and 8 mm diameter were placed into each of the wells in direct contact with the cell culture. none of the test materials was placed into the control group wells. the vitality rate of the cells was evaluated at the end of 24 hours, 72 hours and 7 days by means of mtt test results. results: according to mtt findings, at the end of 24 hours, 72 hours and 7 days the decrease caused by the used materials in the number of the cells was ststistically significant. both materials used found to be cytotoxic after 24 hours, 72 hours and 7 days. conclusion: as the ingredients and filler rates of resin containing materials are important for cytotoxic effects, these specialities should be considered for material selection.