EVALUATION OF PROLIFERATION INDEX IN OSTEOSARCOMA OF JAWS

Aim: osteosarcoma is the most common primary malignant bone tumour that affects frequently long bones of young people. approximately 6 % of all ostesarcoma occurs in jaw bones. jaw osteosarcoma is generally accepted to be a pathologically distinct entity due to older age at presentation, longer median survival, local recurrences and low incidence of metastasis. it has been suggested that better prognosis of jaw osteosarcoma of the jaw bones those in the long bones, may related to the type and the lower stage of the tumour. in this study, proliferation rate of tumour cells in jaw osteosarcoma with comparing long bone osteosarcoma and possible correlation with grading, cellularity and histological type were discussed. materials and method: immunohistochemistry was performed by ki-67 antibody using avidin biotin complex, in a total of 10 ostesarcoma cases and detection of the cells at proliferative phase was performed. results: results of the study displayed the increased ki-67 expression in long bone osteosarcoma cases when compared to the jaw osteosarcoma. the histological grades of jaw osteosarcomas were lower than long bone osteosarcomas. conclusion: these results may be related to the grade of the tumours and explain the different biological behaviours. using proliferation index as a prognostic marker in jaw osteosarcoma could be useful for further researches.