Obesity and Inflammation as Predictors of New-Onset Diabetes Mellitus after Kidney Transplantation

Objective: the clinical impact of new-onset diabetes mellitus (dm) after renal transplantation (rt) is frequently underestimated by clinicians. dm after transplantation is a leading risk factor for cardiovascular events. we aimed to identify post-rt risk factors for nodm. materials and methods: we retrospectively analyzed 236 non-diabetic patients (mean age 41±12 years; %75 male) between 1995 and 2008. we excluded those diagnosed as dm mellitus at rt time (n=23), greft loss during the two years (n =16), acute rejection, congestive heart failure, active infections (n =19), and those for whom data was not fully available (n=3). at 2 years of follow-up after rt, 34 (19.4%) patients developed dm (group 1). one hundred fourthy one non-diabetic patients were defined as group 2. we have recorded parameters at the time of dm diagnosis such as demographic features, medications, smoking history, blood pressure, daily proteinuria. results: age, body mass index, uric acid, sodium, ldl-cholesterol, crp values were significantly higher in group 1. the percentage of weight gain (6.8%±5.2 vs. 5.2%±2.9, p=0.08) were similar in two groups. the prevalence of dm was similar between patients under cya and tac based immu-nosuppression. conclusions: baseline bmi, but not the weight gain at 2 years after rt, is an independent risk factor for dm. importantly, overweight recipients within the high risk group had raised inflammatory markers. tailoring clinical strategies may minimize the impact of this complication.