Castleman’s Disease of Submandibular Gland

Castleman’s disease (cd), or angiofollicular lymph node hyperplasia, is a rare, benign disease of unknown etiology giving rise to lymph node hyperplasia. this disease creates both diagnostic and therapeutic dilemmas for most physicians. tissue biopsy is necessary for a definitive diagnosis. cd of the submandibular gland occurs very rarely. surgery is the treatment of choice for the solitary form in the neck region. we present a 42 year-old woman with cd of submandibular gland together with the review of the literature.