therapeutic impact of platelet-rich plasma on anterior cruciate ligament injury: a mini-review

Platelet-rich plasma (prp) has emerged as a biological approach widely applied to enhance tissue repair and regeneration. this review explored the role of prp in anterior cruciate ligament (acl) reconstruction, focusing on prp terminology, classification, growth factors (gfs), cellular origins, and optimizing platelet dosage in prp therapies. with a variety of gfs derived from distinct cellular sources, prp positively influences tissue repair and regenerative processes. molecular mechanisms and signaling pathways, including hif-1α and p-mtor/t-mtor, are crucial in prp-mediated tissue healing. given prp’s direct involvement in osseo-tendinous convergence and acl reconstruction, understanding the risk factors and contraindications is essential. the findings may contribute to optimizing prp-based treatments for acl regeneration.