Survival Analysis of Osteosarcoma in a University Hospital in Yazd, Iran From 2004 to 2018: A PeriodAnalysis

Background and objectives: osteosarcoma (os) is the most common cause of limb loss due tocancers. this study determines the mean survival time in patients with os and prognostic factors.methods: this retrospective study was conducted on patients with os who were referred toshah vali hospital, yazd, iran, from 2004 to 2018. the data on patient-related factors (age andsex), tumor-related factors (recurrence, recurrence site, and metastasis), and living status wereobtained and analyzed.results: overall, 29 patients were included, of which 21(72.4%) were male. the mean age ofpatients was 21.3±8.4 (age range of 8-42) years. the tumor site was the lower limb in 23 patients(79.3%), the upper limbs in 4 patients (13.8%), and the axial in 2 patients (6.9%). meanwhile,13(44.8%) patients died due to os, and one (6.9%) died for other reasons. the mean survival timein the subjects was 83.1±14.71 months. the 1-year survival of patients was nearly 90%, 3-yearsurvival was about 64%, and 5-year survival was 40%. also, 7(24.1%) patients had primarymetastasis. the mean survival period was 22.25 months in patients with primary metastasis and98.87 months in patients without primary metastasis (p=0.011). among the patients, 15(51.7%)had a recurrence, of which 6(20.7%) were local, and 9(31%) were distant recurrences. the meansurvival period after the recurrence of patients was 21.27±5.07 months.conclusion: the mean survival period, according to sex, age, recurrence, and recurrence site,was not significant; however, it was significant according to metastasis.