fibrinogen dysregulation is a prominent process in fatal conditions of covid-19 infection; a proteomic analysis

Introduction: molecular pathophysiology of covid-19 is not completely known. expression changes in patients' plasma proteins have revealed new information about the disease. introducing the key targeted plasma protein in fatal conditions of covid-19 infection is the aim of this study.methods: significant differentially expressed proteins (deps) in the plasma of cases with a fatal condition of covid-19 were extracted from an original article. these proteins were included in a network via string database along with 100 first neighbor proteins to determine central nodes of the network for analyzing.results: queried and added proteins were included in a scale free network. three hub nodes were identified as critical target proteins. the top queried hub proteins were chains of fibrinogen; fibrinogen alpha chain (fga), fibrinogen gamma chain (fgg), and fibrinogen beta chain (fgb), which are related to the coagulation process.conclusions: it seems that fibrinogen dysregulation has a deep impact on the fatality of covid-19 infection.