new molecular aspects of cardiac arrest; promoting cardiopulmonary resuscitation approaches

Introduction: cardiopulmonary resuscitation (cpr) is a method to improve survival of patients with cardiac arrest. this study aimed to identify the key genes affected five minutes after cardiac arrest, hoping to elevate the efficacy of cpr.methods: in this bioinformatics study differentially expressed genes of six pigswere downloaded from geo and screened. the significant and characterized genes were analyzed via calculating fold change and protein-protein interaction (ppi) networks. the crucial nodes were determined based on centrality parameters and their related biological processes were investigated via cluego. results: 17 significant up-regulated (logfc≥ 2) and 22 down-regulated (logfc < -0.5) genes were detected. transthyretin (ttr logfc = 4.59) and gonadotropin-releasing hormone receptor (gnrhr logfc = 3.84) had higher logfc among up-regulated and down-regulated genes, respectively. the critical genes including four up-regulated and five down-regulated genes were detected from network analysis. gnrhr and prolactin precursor (prl) were among the most important down res 5 minutes after cardiac arrest and beta-2 adrenergic receptor and cadherin-1 were among the most important up regulated gens. conclusion: the introduced potential biomarkers could reveal a new molecular aspect for cpr performance and pituitary gland protection was highlighted in this respect.