early outpatient administration of remdesivir shortens recovery time in patients with mild to moderate covid-19

Background:during covid-19, healthcare systems in underdeveloped nations had significant challenges and were unlikely to offer the necessary care. it appears that a new, reliable healthcare model that prevents hospitalization is necessary to reduce the pressure that covid-19 is putting on healthcare systems and patients. more particularly, as remdesivir's use as an outpatient treatment for mild to severe sars-cov-2 infection has rarely been examined; we aimed to investigate in-depth comprehension of the effects of remdesivir in these cases.methods:in our two-month cross-sectional study, non-hospitalized patients with mild to moderate covid-19 who were referred to the hospital for up to 5 days of remdesivir treatment received 200 mg of remdesivir intravenously on day 1, followed by 100 mg of remdesivir once daily for the subsequent 4 days. patients were divided into groups based on the time of starting remdesivir treatment after the appearance of symptoms: group 1 less than and equal to 7 days, and group 2 more than 7 days. two groups were evaluated for a correlation between remdesivir administration time and clinical symptoms on days 1 and 14 (follow-up visits).results:the study enrolled 273 eligible patients with a mean age of 47.5 years, of whom 112 were males and 125 were females. results showed that patients who received remdesivir in the first 7 days had less dyspnea (p-value<0.0001) and lung involvement (p-value<0.0001) than those who received it after 7 days at the end of the study. patients who came later to receive remdesivir also showed higher fatigue, ast, and alt levels on the first day.conclusions:among patients with moderate covid-19, those who received a 5-day course of remdesivir within 7 days of the onset of symptoms had a statistically significant difference in clinical status compared with those who received their treatments later. however, the size of this finding has uncertain clinical importance.