atorvastatin-induced myalgia in iranian patients: a hospital-based study to determine the prevalence and associated risk factors

Background: statins are associated with several muscle complaints, such as: myositis, myalgia, muscle weakness, muscle spasms and rhabdomyolysis. age, race, gender, dose of statin, concomitant medications, concomitant disorders and genetics have been reported as the most important risk factor for statin-induced myalgia. the aim of this study was to determine the prevalence and associated risk factors of atorvastatin-induced myalgia in hospitalized patients in tehran, iran. methods: in this cross sectional study, a questionnaire was developed by expert panel opinions. the questionnaire was included various items regarding demographic data and myalgia evaluation factors. seven hundred patients were included in the study and necessary data were gathered. finally, the data were analyzed and a statistical model was designed to predict the myalgia risk factors. results: the rate of myalgia was 44.3% among studied patients. by developing a multivariate logistic model, female gender (or= 0.47, p-value<0.001) was one of the most important factors in myalgia occurrence. conclusion: the results of this study suggest that gender, age, atorvastatin dose, duration of atorvastatin usage and presence of myotoxic disease are the main predictors of myalgia in iranian population. hence, the findings of this study can be considered to predict the myalgia incidence risk in iranian population.