Antibacterial Resistance Patterns of Helicobacter pylori Clinical Isolates From Gastric Biopsy of Patients in Yazd

Background: helicobacter pylori related-infections are common in developing countries, including iran. however, little information is available on the antibiotic susceptibility of h. pylori in yazd. objectives: the aim of this study was to investigate the antibiotic resistance patterns of h. pylori isolates from gastric biopsy of patients in yazd. materials and method: in this descriptive-analytical study, 651 gastric biopsy specimens were taken from may 2012 to february 2013. samples were cultured into selective brucella agar media. after 3 to 10 days of incubation and identification of bacteria by using gram stain and biochemical tests, antibacterial susceptibility assay was performed by disk diffusion method. results: all of 651 gastric biopsy specimens were cultured and 144 (22.12%) isolates of h. pylori were collected. in total, 76 (52.7%) of 144 h. pylori isolates were isolated from females and 68 (47.2%) from males. rate of antibiotic resistance to metronidazole, tetracycline, clarithromycin, levofloxacin, ciprofloxacin and amoxicillin were 77.8%, 21.5%, 18.8%, 14.6%, 19.4% and 7.6%, respectively. no antibiotic resistance was found against furazolidone. there was no significant association between these isolates antibiotics resistance with sex, age and endoscopic diagnoses (p > 0.05). conclusions: h. pylori isolates resistance was high to antibiotics, especially metronidazole. therefore, determining resistance pattern of h. pylori isolates is recommended in all parts of the country.