side effects of covid-19 vaccination among healthcare workers in tehran, iran

Background: since the emergence of coronavirus disease 2019 (covid-19), many people have been vaccinated worldwide. despite the preventive role of vaccines, their side effects face disease management with challenges. this study aims to investigate the side effects of covid-19 vaccination among healthcare workers in tehran, iran.methods: this cross-sectional study was conducted from april to october 2022 on 377 healthcare workers in tehran, iran. data collection was carried out through an interview by a researcher using a checklist assessing systemic and local side effects of covid-19 vaccines.results: the mean age of participants was 36.03±10.24 years, and 68.2% were female. participants experienced significantly more local (26.5% vs. 14.3%, p<0.001) and systemic (52.0% vs. 31.8%, p<0.001) side effects after the first dose than after the second dose. after the first dose, astrazeneca (45.9%) caused significantly more local reactions than sputnik v (21.7%) and sinopharm (14.5%). astrazeneca (83.7%) caused significantly more systemic side effects than sputnik v (50.7%) and sinopharm (14.5%). the prevalence of local and systemic side effects after the first dose was significantly different in terms of vaccine types (p<0.001). after the second dose, astrazeneca (20.4%) caused significantly more local reactions than sputnik v (12.8%) and sinopharm (10.5%) (p<0.001). additionally, astrazeneca (38.8%) and sputnik v (37.4%) caused significantly more systemic side effects than sinopharm (7.9%) (p<0.001).conclusion: most healthcare workers in tehran experienced flu-like symptoms and local reactions at the injection site after vaccination against covid-19, mainly after the first dose. they had more side effects after vaccination with astrazeneca and sputnik v, compared to sinopharm.