Examining Metabolic Profiles in Opioid-Dependent Patient

Background: drug abuse is a social burden and a public health disorder. previous evidence suggested numerous illicit substances (e.g., opioids, amphetamines, cocaine, & cannabis) affect immune system functions, oxidative stress mechanisms, inflammatory cytokines, and reactive oxygen species production. this study aimed to determine the extent of these metabolic parameters in opioid-dependent patients. we also compared these patients with a healthy control group. methods: this study was conducted in amirie clinic, kashan, iran. plasma and serum samples from 50 illicit opioid users (study group) and 50 non-opioid users (control group) were studied. metabolic levels for mda, no, tac, gsh, insulin, homa-ir, and hs-crp were assessed in both research groups (n=100). results: there was a significant difference in the status of mda (p=0.003), no (p=0.01), tac (p=0.003), gsh (p=0.001), insulin (p=0.04), homa-ir (p=0.02), and hs-crp (p=0.001) between the study and control groups. furthermore, there was a significant correlation among the duration of illicit opioid use and mda concentrations (r=-0.424, p=0.002), as well as tac levels (r=0.314, p=0.02). conclusion: the study results suggested metabolic profiles were impaired in the study group, compared to the controls.